Endocrine Abstracts

Obesity has become one of the greatest public health concerns and is known to be a major risk factor for cardiac, respiratory and metabolic diseases. Bariatric surgery is the most effective treatment for morbid obesity. According with guidelines, surgery is indicated for treatment of patients with BMI greater than 40 kg/m2 or above 35 kg/m2, with at least one obesity-related comorbid condition, such as as type 2 diabetes, hypertension, dyslipidemia, sleep...

Bariatric surgery is the most-effective treatment for morbid obesity, superior to medical treatment. Metabolic syndrome (MS) is a condition characterized by multiple major risk factors for coronary heart disease, diabetes, fatty liver, and several cancers; the main, diagnostic, components of MS are low HDL-cholesterol (<40 mg/dl in man, <50 mg/dl in woman), raised triglycerides (>150 mg/dl), blood pressure >130/85 mmHg, fasting plasma glucose >100 mg/dl and...

Introduction: Cushing’s syndrome (CS) is associated with increased mortality and morbidities. Hypercortisolism is also present in chronic mood disorders (CMD) and stress, where telomere length (TL) has been found to be shorter than in matched controls. Since hypercortisolism is present in CS and CMD, we hypothesized that telomere shortening could also be present in CS. The aim of this study was to investigate TL in CS patients compared to matched controls.<p class="ab...

Background: So far, guidelines for bariatric surgery do no recommend the universal screening for thyroid diseases, except the TSH measurement in selected patients. However, a possible interplay between obesity (possibly complicated by obesity-related comorbidities) and thyroid diseases has been postulated.Objective: Aim of the study was to investigate the prevalence of thyroid diseases in a cohort of obese patients, evaluated for bariatric surgery. Metho...

Objective: Osteoporosis and vertebral fractures (VFs) are frequently observed in HIV-infected men. Whereas bisphosphonates seem effective on bone mineral density (BMD) maintenance in HIV-men, data on VFs are lacking. We aimed to evaluate the long-term efficacy of bisphosphonates on VFs in HIV-infected men.Design: Real-life longitudinal retrospective study on 118 consecutive HIV-infected males (median age at inclusion 53 years). Median time between first ...

Introduction: Correct titration of basal insulin is one of the most important conditions allowing Type 2 Diabetes Mellitus patients to reach correct and personalised fasting plasma glucose. The persistence of the pandemic, together with the persistence of the SARS-CoV2 virus made titration process more complex, and pushed the Lombardy diabetologists to develop solutions which could be handled by the patient independently, or with the remote online assistance of diabetes team.<...

Objective: Adrenal venous sampling (AVP) is a reliable procedure to differentiate if in patients with primary aldosteronism (PA) aldosterone production is unilateral or bilateral and guide the treatment of these patients. Our objective was to describe their characteristics and the outcomes of the AVPs.Methods and patients: Observational longitudinal clinical study between July 2020 and September 2021 in patients who underwent AVP in our Hospital.<p c...

Objective: An enhancement of the response rate has been recently showed in patients with Graves’ ophthalmopathy (GO) treated with corticosteroids and mycophenolic acid. In GO, retro-orbital cells showed a cytokine-induced secretion of Th1 and Th2 chemokines. Since no data are present in literature about the effect of corticosteroids and mycophenolic acid on the chemokines secretion in GO orbital cells, we aim to deepen out this topic.Methods: We est...

Objective: Describe clinical, laboratorial, imaging features, therapeutic management and the outcomes of patients with clinically non-functioning pituitary adenomas (NFPAs) presenting at our department.Methods: Retrospective review of electronic medical records of all patients with NFPAs evaluated at our department between 2010 and 2019.Results: We evaluated 160 patients, 51.3% female, with a median age of 56.6 years (18–89). ...

Background: Pheochromocytoma is a rare catecholamine secreting tumor originating usually from adrenal medulla and representing approximately 5% of adrenal incidentalomas. Currently 10% of all pheochromocytomas are discovered incidentally during imaging studies for unrelated disorders.Case presentation: A thirty five year old woman with no relevant medical history presented at the emergency department with symptoms of left flank pain and vomiting. Abdomin...